CANCER TEST

CANCER


Normally, human cells grow and divide to form new cells as they are body’s basic building blocks. The new cells will replace the old, damaged or dead cells. The development of cancer is uncontrolled growth of abnormal cells due to a series of permanent changes in the nucleotide sequence (mutation). This changes can be inherited from parents or induced by environment and lifestyle. The cancer cells can spread to nearby tissues and other organs through the blood and lymphatic systems. As a result, those organs lose their normal functions and eventually lead to patient’s death.




HEREDITARY CANCER

Approximately 5% - 10% of all cancers are hereditary that is passing the mutated genes from parents to offsprings. The risk of developing a cancer increases significantly when there is a medical history among family members. In early stages, most cancers usually have no symptoms.

TUMOR SYNDROMES TEST

Tumor Syndromes Test is a multi-gene test that detects mutations in genes which have an association with an increased risk of developing hereditary cancers. This panel covers ≥120 genes that allowing the identification of mutations related with colorectal cancer, breast cancer, ovarian cancer, pheochromocytomas, paragangliomas, other selected familial tumors.

By performing a comprehensive cancer-related genes analysis, a more accurate result can be provided with lower cost and shorter time compared with single syndrome testing.





LIST OF GENES WITH ASSOCIATED CANCERS


ASSOCIATED CANCER/SYNDROME TOTAL NO. OF GENES LIST OF GENES
Colon Cancer 26 APC, AXIN2, BMPR1A, CDH1, CHEK2, EPCAM, FLCN, GREM1, MLH1, MSH2, MSH3, MSH6, MUTYH, NBN, NTHL1, PMS2, POLD1, POLE, PTEN, RINT1, RNF43, RPS20, SCG5, SMAD4, STK11, TP53
Colon Cancer -
Polyposis Coli
14 APC , BMPR1A , CHEK2, GREM1, MSH3, MUTYH , NTHL1, POLD1, POLE, PTEN, RNF43, SCG5, SMAD4, STK11
Colon Cancer -
Hereditary Non-Polyposis Colon Cancer
5 EPCAM, MLH1, MSH2, MSH6, PMS2
Gastric Cancer 10 BRCA2, CDH1, EPCAM, IL1B, IL1RN, KIT, MLH1, MSH2, MSH6, PMS2
Cowden Syndrome 6 AKT1, PIK3CA, PTEN, SDHB, SDHD, SEC23B
Breast Cancer

Ovarian Cancer
40 ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, EPCAM, FAM175A, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HOXB13, MEN1, MLH1, MRE11A, MSH2, MSH3, MSH6, MUTYH, NBN, NF1, PALB2, PMS2, PTCH1, PTEN, RAD50, RAD51C, RAD51D, RINT1, SDHB, SDHC, SDHD, SLX4, STK11, TP53, XRCC2
Pancreatic Cancer 17 ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, EPCAM, FAM175A, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, MEN1, MLH1, MRE11A, MSH2, MSH3, MSH6, MUTYH, NBN, NF1, PALB2, PMS2, PTCH1, PTEN, RAD50, RAD51C, RAD51D, RINT1, SDHB, SDHC, SDHD, SLX4, STK11, TP53, XRCC2
Prostate Cancer 11 BRCA1, BRCA2, CHEK2, EPCAM, HOXB13, MLH1, MSH2, MSH6, NBN, PMS2, TP53
Renal Cell Carcinoma 28 BAP1, CCDN1, CDC73, DIS3L2, EPCAM, FH, FLCN, HNF1A, HNF1B, MET, MITF, MLH1, MSH2, MSH6, PALB2, PMS2, PTEN, SDHA, SDHAF2, SDHB, SDHC, SDHD, TP53, TSC1, TSC2, VHL, WT1
Melanoma 15 BAP1, BRCA2, CDK4, CDKN2A, EPCAM, MC1R, MITF, MLH1, MSH2, MSH6, PMS2, POT1, PTEN, RB1, TP53
Fanconi Anemia 21 BRCA1, BRCA2, BRIP1, ERCC4, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, MAD2L2, PALB2, RAD51, RAD51C, SLX4, UBE2T, XRCC2
Xeroderma Pigmentosum 9 DDB2, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, POLH, XPA, XPC
Pheochromocytoma
Paraganglioma
14 CDKN1B, MAX, MEN1, NF1, PRKAR1A, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, SRGAP1, TMEM127, VHL
Other Familial Tumor Syndromes 53 AIP, AKT1, ALK, APC, ATR, BAP1, BLM, BRCA2, CDC73, CDH1, CDKN1C, CDKN2A, CYLD, DICER1, EPCAM, FH, HRAS, IL1B, IL1RN, KIT, LIG4, LZTR1, MET, MLH1, MSH2, MSH6, NBN, NF1, NF2, PIK3CA, PMS2, PTEN, RASAL1, RB1, RECQL4, RET, RHBDF2, SDHA, SDHB, SDHC, SDHD, SEC23B, SMARCA4, SMARCB1, SMARCE1, SPRED1, SUFU, TP53, TSC1, TSC2, VHL, WRN, YAP1
Central Nervous Sytem Tumor 18 AIP, APC, BRCA2, MLH1, MSH2, MSH6, NF1, NF2, PMS2, PTEN, SDHA, SDHB, SDHD, SMARCE1, SPRED1, SUFU, TP53, VHL

PROCESS OF EXAMINATION




CeGaT


CeGaT (Center for Genomics and Transcriptomes) is a Germany-based leading provider of genetic diagnostic services.
  • 7 years of experience in genetic diagnostic services
  • Interdisciplinary team of scientists and medical doctors
  • Well-established genetic diagnostic panels including disease detection and recommended treatment
  • Accredited by both international and national standards






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